Detalles de la búsqueda
1.
Rationale and design of the AXIOMATIC-SSP phase II trial: Antithrombotic treatment with factor XIa inhibition to Optimize Management of Acute Thromboembolic events for Secondary Stroke Prevention.
J Stroke Cerebrovasc Dis
; 31(10): 106742, 2022 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-36037679
2.
A multi-national trial of a direct oral anticoagulant in children with cardiac disease: Design and rationale of the Safety of ApiXaban On Pediatric Heart disease On the preventioN of Embolism (SAXOPHONE) study.
Am Heart J
; 217: 52-63, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31493728
3.
Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus.
Bioorg Med Chem Lett
; 27(3): 590-596, 2017 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28011221
4.
Pseudosaccharin amines as potent and selective KV1.5 blockers.
Bioorg Med Chem Lett
; 25(21): 4983-4986, 2015 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25801931
5.
Design, synthesis and evaluation of phenethylaminoheterocycles as K(v)1.5 inhibitors.
Bioorg Med Chem Lett
; 24(14): 3018-22, 2014 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24881565
6.
Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent.
Bioorg Med Chem Lett
; 24(5): 1294-8, 2014 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24513044
7.
Safety and efficacy of factor XIa inhibition with milvexian for secondary stroke prevention (AXIOMATIC-SSP): a phase 2, international, randomised, double-blind, placebo-controlled, dose-finding trial.
Lancet Neurol
; 23(1): 46-59, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-38101902
8.
Antiplatelet Treatment Patterns and Outcomes for Secondary Stroke Prevention in the United Kingdom.
Cardiol Ther
; 12(4): 675-687, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37789237
9.
First-in-human study of milvexian, an oral, direct, small molecule factor XIa inhibitor.
Clin Transl Sci
; 15(2): 330-342, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34558200
10.
Single-Dose Pharmacokinetics of Milvexian in Participants with Normal Renal Function and Participants with Moderate or Severe Renal Impairment.
Clin Pharmacokinet
; 61(10): 1405-1416, 2022 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-35906349
11.
Single-Dose Pharmacokinetics of Milvexian in Participants with Mild or Moderate Hepatic Impairment Compared with Healthy Participants.
Clin Pharmacokinet
; 61(6): 857-867, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35262846
12.
Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers.
Bioorg Med Chem Lett
; 20(4): 1436-9, 2010 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20097068
13.
Position 5.46 of the serotonin 5-HT2A receptor contributes to a species-dependent variation for the 5-HT2C agonist (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one: impact on selectivity and toxicological evaluation.
Mol Pharmacol
; 76(6): 1211-9, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19767451
14.
Dihydropyrazolopyrimidines containing benzimidazoles as K(V)1.5 potassium channel antagonists.
Bioorg Med Chem Lett
; 19(18): 5469-73, 2009 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19665893
15.
PREVAPIX-ALL: Apixaban Compared to Standard of Care for Prevention of Venous Thrombosis in Paediatric Acute Lymphoblastic Leukaemia (ALL)-Rationale and Design.
Thromb Haemost
; 119(5): 844-853, 2019 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-30861550
16.
Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing.
J Med Chem
; 59(17): 8042-60, 2016 09 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27564532
17.
Consequences of atrial tachycardia-induced remodeling depend on the preexisting atrial substrate.
Circulation
; 105(2): 251-7, 2002 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-11790709
18.
Enalapril effects on atrial remodeling and atrial fibrillation in experimental congestive heart failure.
Cardiovasc Res
; 54(2): 456-61, 2002 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-12062350
19.
Evolution of the atrial fibrillation substrate in experimental congestive heart failure: angiotensin-dependent and -independent pathways.
Cardiovasc Res
; 60(2): 315-25, 2003 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-14613861
20.
Randomized, Double-Blind, Phase 3 Trial of Triple Therapy With Dapagliflozin Add-on to Saxagliptin Plus Metformin in Type 2 Diabetes.
Diabetes Care
; 38(11): 2009-17, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26246458